The Anti-tumor Activity of 2-keto-3-ethoxybutyraldehyde Bis(thiosemicarbazone) and Related Compounds.
نویسندگان
چکیده
2-Keto-3-ethoxybutyraldehyde bis(thiosemicarbazone) (KTS) has been shown to have marked carcinostatic and carcinolytic activity against several established rat tu mors. Dose-response relationships have been established for its toxicity, tumor-in hibitory activity, and capability of causing regressions. The compound is more safely administered via the oral route than by intraperitoneal injection. The activity of KTS is compared with several related compounds, and some indica tions of structural requirements for biological activity are noted.
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ورودعنوان ژورنال:
- Cancer research
دوره 24 شماره
صفحات -
تاریخ انتشار 1964